Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Identifieur interne : 000244 ( Main/Exploration ); précédent : 000243; suivant : 000245Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Auteurs : Matti Vornanen ; Minna Hassinen ; Jaakko HaverinenSource :
- Marine Drugs [ 1660-3397 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Canaux sodiques (effets des médicaments et des substances chimiques), Canaux sodiques (métabolisme), Myocytes cardiaques (effets des médicaments et des substances chimiques), Myocytes cardiaques (métabolisme), Relation dose-effet des médicaments (MeSH), Résistance aux substances (MeSH), Spécificité d'espèce (MeSH), Techniques in vitro (MeSH), Tétrodotoxine (administration et posologie), Tétrodotoxine (toxicité), Vertébrés (MeSH).
- MESH :
- administration et posologie : Tétrodotoxine.
- effets des médicaments et des substances chimiques : Canaux sodiques, Myocytes cardiaques.
- métabolisme : Canaux sodiques, Myocytes cardiaques.
- toxicité : Tétrodotoxine.
- Animaux, Relation dose-effet des médicaments, Résistance aux substances, Spécificité d'espèce, Techniques in vitro, Vertébrés.
English descriptors
- KwdEn :
- Animals (MeSH), Dose-Response Relationship, Drug (MeSH), Drug Resistance (MeSH), In Vitro Techniques (MeSH), Myocytes, Cardiac (drug effects), Myocytes, Cardiac (metabolism), Sodium Channels (drug effects), Sodium Channels (metabolism), Species Specificity (MeSH), Tetrodotoxin (administration & dosage), Tetrodotoxin (toxicity), Vertebrates (MeSH).
- MESH :
- chemical , administration & dosage : Tetrodotoxin.
- chemical , drug effects : Sodium Channels.
- drug effects : Myocytes, Cardiac.
- metabolism : Myocytes, Cardiac, Sodium Channels.
- chemical , toxicity : Tetrodotoxin.
- Animals, Dose-Response Relationship, Drug, Drug Resistance, In Vitro Techniques, Species Specificity, Vertebrates.
Abstract
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac INa was highly TTX-sensitive with EC50-values between 1.4 and 6.6 nmol·L−1. In the snake heart, about 80% of the INa was TTX-resistant with EC50 value of 0.65 μmol·L−1, the rest being TTX-sensitive (EC50 = 0.5 nmol·L−1). Although TTX-resistance of the cardiac INa appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na+ channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates.
Url:
DOI: 10.3390/md9112409
PubMed: 22163193
PubMed Central: 3229242
Affiliations:
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Le document en format XML
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xml:lang="en"><term>Animals (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Drug Resistance (MeSH)</term><term>In Vitro Techniques (MeSH)</term><term>Myocytes, Cardiac (drug effects)</term><term>Myocytes, Cardiac (metabolism)</term><term>Sodium Channels (drug effects)</term><term>Sodium Channels (metabolism)</term><term>Species Specificity (MeSH)</term><term>Tetrodotoxin (administration & dosage)</term><term>Tetrodotoxin (toxicity)</term><term>Vertebrates (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Canaux sodiques (effets des médicaments et des substances chimiques)</term><term>Canaux sodiques (métabolisme)</term><term>Myocytes cardiaques (effets des médicaments et des substances chimiques)</term><term>Myocytes cardiaques (métabolisme)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Résistance aux substances (MeSH)</term><term>Spécificité d'espèce (MeSH)</term><term>Techniques in vitro (MeSH)</term><term>Tétrodotoxine (administration et posologie)</term><term>Tétrodotoxine (toxicité)</term><term>Vertébrés (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Tetrodotoxin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Sodium Channels</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Tétrodotoxine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Myocytes, Cardiac</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Canaux sodiques</term><term>Myocytes cardiaques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Myocytes, Cardiac</term><term>Sodium Channels</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canaux sodiques</term><term>Myocytes cardiaques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Tetrodotoxin</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Tétrodotoxine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Drug Resistance</term><term>In Vitro Techniques</term><term>Species Specificity</term><term>Vertebrates</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Relation dose-effet des médicaments</term><term>Résistance aux substances</term><term>Spécificité d'espèce</term><term>Techniques in vitro</term><term>Vertébrés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na<sup>+</sup> current (I<sub>Na</sub>) is still unresolved. To this end, TTX sensitivity of the cardiac I<sub>Na</sub> was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac I<sub>Na</sub> was highly TTX-sensitive with EC<sub>50</sub>-values between 1.4 and 6.6 nmol·L<sup>−1</sup>. In the snake heart, about 80% of the I<sub>Na</sub> was TTX-resistant with EC<sub>50</sub> value of 0.65 μmol·L<sup>−1</sup>, the rest being TTX-sensitive (EC<sub>50</sub> = 0.5 nmol·L<sup>−1</sup>). Although TTX-resistance of the cardiac I<sub>Na</sub> appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na<sup>+</sup> channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lopreato, G F" uniqKey="Lopreato G">G.F. Lopreato</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name></author><author><name sortKey="Southwell, A" uniqKey="Southwell A">A. Southwell</name></author><author><name sortKey="Atkinson, N S" uniqKey="Atkinson N">N.S. Atkinson</name></author><author><name sortKey="Hillis, D M" uniqKey="Hillis D">D.M. Hillis</name></author><author><name sortKey="Wilcox, T P" uniqKey="Wilcox T">T.P. Wilcox</name></author><author><name sortKey="Zakon, H H" uniqKey="Zakon H">H.H. 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Haverinen</name></author><author><name sortKey="Vornanen, M" uniqKey="Vornanen M">M. Vornanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hassinen, M" uniqKey="Hassinen M">M. Hassinen</name></author><author><name sortKey="Paajanen, V" uniqKey="Paajanen V">V. Paajanen</name></author><author><name sortKey="Haverinen, J" uniqKey="Haverinen J">J. Haverinen</name></author><author><name sortKey="Eronen, H" uniqKey="Eronen H">H. Eronen</name></author><author><name sortKey="Vornanen, M" uniqKey="Vornanen M">M. Vornanen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hassinen, Minna" sort="Hassinen, Minna" uniqKey="Hassinen M" first="Minna" last="Hassinen">Minna Hassinen</name><name sortKey="Haverinen, Jaakko" sort="Haverinen, Jaakko" uniqKey="Haverinen J" first="Jaakko" last="Haverinen">Jaakko Haverinen</name><name sortKey="Vornanen, Matti" sort="Vornanen, Matti" uniqKey="Vornanen M" first="Matti" last="Vornanen">Matti Vornanen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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